• 靶点：
• v-SNARE Vti1a

• 简介：
• >>SNARE interactions in vesicular transport

• 基因名称：
• VTI1A

• 蛋白名称：
• Vesicle transport through interaction with t-SNAREs homolog 1A

• Human Gene Id：
• 143187

• Human Swiss Prot No：
• Q96AJ9

• Mouse Gene Id：
• 53611

• Mouse Swiss Prot No：
• O89116

• Rat Gene Id：
• 65277

• Rat Swiss Prot No：
• Q9JI51

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human VTI1A. AA range:31-80

• 特异性：
• v-SNARE Vti1a Polyclonal Antibody detects endogenous levels of v-SNARE Vti1a protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• VTI1A;Vesicle transport through interaction with t-SNAREs homolog 1A;Vesicle transport v-SNARE protein Vti1-like 2;Vti1-rp2

• 实测条带：
• 23kD

• 背景：
• The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

• 功能：
• function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.,similarity:Belongs to the VTI1 family.,

• 细胞定位：
• Cytoplasmic vesicle . Golgi apparatus membrane ; Single-pass type IV membrane protein .

• 组织表达：
• Lung,

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