• 靶点：
• VAMP4

• 简介：
• >>SNARE interactions in vesicular transport

• 基因名称：
• VAMP4

• 蛋白名称：
• Vesicle-associated membrane protein 4

• Human Gene Id：
• 8674

• Human Swiss Prot No：
• O75379

• Mouse Swiss Prot No：
• O70480

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50

• 特异性：
• VAMP-4 Polyclonal Antibody detects endogenous levels of VAMP-4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• VAMP4;Vesicle-associated membrane protein 4;VAMP-4

• 分子量：
• 16kD

• 背景：
• Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008],

• 功能：
• function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A.,

• 细胞定位：
• Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein . Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.

• 组织表达：
• B-cell,Bone marrow,Epithelium,Liver,Urinary bladder,

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