• 靶点：
• USP48

• 基因名称：
• USP48

• 蛋白名称：
• Ubiquitin carboxyl-terminal hydrolase 48

• Human Gene Id：
• 84196

• Human Swiss Prot No：
• Q86UV5

• Mouse Gene Id：
• 170707

• Mouse Swiss Prot No：
• Q3V0C5

• Rat Gene Id：
• 362636

• Rat Swiss Prot No：
• Q76LT8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human USP48. AA range:631-680

• 特异性：
• USP48 Polyclonal Antibody detects endogenous levels of USP48 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• USP48;USP31;Ubiquitin carboxyl-terminal hydrolase 48;Deubiquitinating enzyme 48;Ubiquitin thioesterase 48;Ubiquitin-specific-processing protease 48

• 实测条带：
• 120kD

• 背景：
• This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:Was named USP31 by some authors (PubMed:15354349 and PubMed:17081983).,function:Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 3 DUSP domains.,subunit:Interacts with TRAF2 and RELA.,tissue specificity:Widely expressed.,

• 细胞定位：
• Cytoplasm . Nucleus .

• 组织表达：
• Widely expressed.

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