USP45 Polyclonal Antibody
- 货号：YT4842
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 蛋白名称：
- Ubiquitin carboxyl-terminal hydrolase 45
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human USP45. AA range:301-350
- 特异性：
- USP45 Polyclonal Antibody detects endogenous levels of USP45 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- USP45;Ubiquitin carboxyl-terminal hydrolase 45;Deubiquitinating enzyme 45;Ubiquitin thioesterase 45;Ubiquitin-specific-processing protease 45
- 背景：
- The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016],
- 功能：
- catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.,
- 细胞定位：
- Photoreceptor inner segment . Cytoplasm . Nucleus .
- 组织表达：
- Widely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563).
- Western blot analysis of USP45 Antibody. The lane on the right is blocked with the USP45 peptide.
