• 靶点：
• Tollip

• 简介：
• >>Toll-like receptor signaling pathway

• 基因名称：
• TOLLIP

• 蛋白名称：
• Toll-interacting protein

• Human Gene Id：
• 54472

• Human Swiss Prot No：
• Q9H0E2

• Mouse Swiss Prot No：
• Q9QZ06

• 免疫原：
• Synthesized peptide derived from the Internal region of human Tollip.

• 特异性：
• Tollip Polyclonal Antibody detects endogenous levels of Tollip protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TOLLIP;Toll-interacting protein

• 实测条带：
• 30kD

• 背景：
• This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],

• 功能：
• function:Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.,PTM:Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.,similarity:Contains 1 CUE domain.,subunit:Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Brain,Eye,Placenta,Testis,

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