• 靶点：
• TAT

• 简介：
• >>Ubiquinone and other terpenoid-quinone biosynthesis;>>Cysteine and methionine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways

• 基因名称：
• TAT

• 蛋白名称：
• Tyrosine aminotransferase

• Human Gene Id：
• 6898

• Human Swiss Prot No：
• P17735

• Mouse Gene Id：
• 234724

• Mouse Swiss Prot No：
• Q8QZR1

• Rat Gene Id：
• 24813

• Rat Swiss Prot No：
• P04694

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TAT. AA range:255-304

• 特异性：
• TAT Polyclonal Antibody detects endogenous levels of TAT protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TAT;Tyrosine aminotransferase;TAT;L-tyrosine:2-oxoglutarate aminotransferase

• 分子量：
• 50kD

• 背景：
• This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,disease:Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.,pathway:Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 2/6.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,

• 细胞定位：
• mitochondrion,cytosol,

• 组织表达：
• Liver,

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs