TALK-2 Polyclonal Antibody
- 货号：YT4539
- 应用：WB;ELISA
- 种属：Human
- 蛋白名称：
- Potassium channel subfamily K member 17
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human KCNK17. AA range:271-320
- 特异性：
- TALK-2 Polyclonal Antibody detects endogenous levels of TALK-2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- KCNK17;TALK2;TASK4;Potassium channel subfamily K member 17;2P domain potassium channel Talk-2;Acid-sensitive potassium channel protein TASK-4;TWIK-related acid-sensitive K(+) channel 4;TWIK-related alkaline pH-activated K(+) channel
- 背景：
- potassium two pore domain channel subfamily K member 17(KCNK17) Homo sapiens The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
- 功能：
- function:Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.,miscellaneous:Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,
- 细胞定位：
- Membrane; Multi-pass membrane protein.
- 组织表达：
- Adrenal gland,Lung,Pancreas,Spleen,
- Immunofluorescence analysis of Caco2 cell. 1,primary Antibody was diluted at 1:100(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - AFluor 594 Secondary antibody(catalog No: RS3611) was diluted at 1:500(room temperature, 50min).
- Western blot analysis of lysates from Jurkat cells, using KCNK17 Antibody. The lane on the right is blocked with the synthesized peptide.
