T2R49 Polyclonal Antibody
- 货号：YT4513
- 应用：WB;IF;ELISA
- 种属：Human
- 蛋白名称：
- Taste receptor type 2 member 20
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human TAS2R49. AA range:94-143
- 特异性：
- T2R49 Polyclonal Antibody detects endogenous levels of T2R49 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TAS2R20;TAS2R49;Taste receptor type 2 member 20;Taste receptor type 2 member 49;T2R49;Taste receptor type 2 member 56;T2R56
- 背景：
- This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016],
- 功能：
- function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,
- 细胞定位：
- Membrane; Multi-pass membrane protein.
- 组织表达：
- Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
- Western blot analysis of lysates from COLO and HepG2 cells, using TAS2R49 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from COLO205 cells using TAS2R49 antibody.
