T2R1 Polyclonal Antibody

    • 货号:YT4503
    • 应用:WB;ELISA;IHC
    • 种属:Human
      • 靶点:
      • T2R1
      • 简介:
      • >>Taste transduction
      • 基因名称:
      • TAS2R1
      • 蛋白名称:
      • Taste receptor type 2 member 1
      • Human Swiss Prot No:
      • Q9NYW7
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human TAS2R1. AA range:6-55
      • 特异性:
      • T2R1 Polyclonal Antibody detects endogenous levels of T2R1 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • TAS2R1;Taste receptor type 2 member 1;T2R1;Taste receptor family B member 7;TRB7
      • 实测条带:
      • 33kD
      • 背景:
      • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,
      • 细胞定位:
      • Membrane; Multi-pass membrane protein.
      • 组织表达:
      • Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
      • 产品图片
      • Western blot analysis of lysates from MCF-7 cells, using TAS2R1 Antibody. The lane on the right is blocked with the synthesized peptide.
      • Western blot analysis of the lysates from K562 cells using TAS2R1 antibody.
      • Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).