- 首页
- 公司介绍
- 热门促销
-
全部产品
-
试剂盒
- |
-
一抗
- |
-
二抗
- |
-
蛋白
- |
-
免疫组化试剂
- |
-
WB 试剂
- PonceauS Staining Solution
- PBST Washing Buffer, 10X
- 1.5M Tris-HCl Buffer, pH8.8
- 1M Tris-HCl Buffer, pH6.8
- 10% SDS Solution
- Prestained Protein Marker
- TBST Washing Buffer, 10X
- SDS PAGE Loading Buffer, 5X
- Stripping Buffered Solution
- Tris Buffer, pH7.4, 10X
- Total Protein Extraction Kit
- Running Buffer, 10X
- Transfer Buffer, 10X
- 30% Acr-Bis(29:1) Solution
- Tris电泳液速溶颗粒
- PBS(1X, premixed powder)
- TBS(1X, premixed powder)
- 快速封闭液
- 转膜液速溶颗粒
- Chemical reagents
- 公司新闻
- 营销网络
- 资源中心
- 联系我们
SSH3 Polyclonal Antibody
- 货号:YT4428
- 应用:WB;IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Axon guidance;>>Regulation of actin cytoskeleton
- 蛋白名称:
- Protein phosphatase Slingshot homolog 3
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human SSH3. AA range:357-406
- 特异性:
- SSH3 Polyclonal Antibody detects endogenous levels of SSH3 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- SSH3;SSH3L;Protein phosphatase Slingshot homolog 3;SSH-like protein 3;SSH-3L;hSSH-3L
- 背景:
- The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
- 功能:
- catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,
- 细胞定位:
- Cytoplasm, cytoskeleton . Nucleus .
- 组织表达:
- Cerebellum,Epithelium,Ovarian carcinoma,Uterus,
![](/uploadfiles/PIC/yt4428-wb.jpg)
- Western Blot analysis of various cells using SSH3 Polyclonal Antibody
![](/uploadfiles/PIC/yt4428_pic737618522.jpg)
- Western blot analysis of SSH3 Antibody. The lane on the right is blocked with the SSH3 peptide.
![](/uploadfiles/PIC/yt4428_pic737718522.jpg)
- Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using SSH3 Antibody. The lane on the right is blocked with the SSH3 peptide.
![](/uploadfiles/PIC/yt4428_pic1065718522.jpg)
- Western blot analysis of the lysates from K562 cells using SSH3 antibody.