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SIRT3 Polyclonal Antibody

货号：YT4304
应用：WB;ELISA
种属：Human;Mouse;

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靶点：
SIRT3

简介：
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Central carbon metabolism in cancer

基因名称：
SIRT3

蛋白名称：
NAD-dependent protein deacetylase sirtuin-3 mitochondrial

Human Gene Id：
23410

Human Swiss Prot No：
Q9NTG7

Mouse Swiss Prot No：
Q8R104

免疫原：
The antiserum was produced against synthesized peptide derived from human SIRT3. AA range:350-399

特异性：
SIRT3 Polyclonal Antibody detects endogenous levels of SIRT3 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
SIRT3;SIR2L3;NAD-dependent protein deacetylase sirtuin-3; mitochondrial;hSIRT3;Regulatory protein SIR2 homolog 3;SIR2-like protein 3

实测条带：
45kD

背景：
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008],

功能：
catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,function:NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,tissue specificity:Widely expressed.,

细胞定位：
Mitochondrion matrix .

组织表达：
Widely expressed.

CD90 affects the biological behavior and energy metabolism level of gastric cancer cells by targeting the PI3K/AKT/HIF‑1α signaling pathway. Oncology Letters Oncol Lett. 2021 Mar;21(3):1-1 WB Human 1:1000 AGS cell
货号：YT4304