• 靶点：
• Sar1B

• 简介：
• >>Protein processing in endoplasmic reticulum;>>Legionellosis

• 基因名称：
• SAR1B

• 蛋白名称：
• GTP-binding protein SAR1b

• Human Gene Id：
• 51128

• Human Swiss Prot No：
• Q9Y6B6

• Mouse Gene Id：
• 66397

• Mouse Swiss Prot No：
• Q9CQC9

• Rat Gene Id：
• 287276

• Rat Swiss Prot No：
• Q5HZY2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SAR1B. AA range:111-160

• 特异性：
• Sar1B Polyclonal Antibody detects endogenous levels of Sar1B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SAR1B;SARA2;SARB;GTP-binding protein SAR1b;GTP-binding protein B;GTBPB

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010],

• 功能：
• disease:Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.,function:Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.,similarity:Belongs to the small GTPase superfamily.,similarity:Belongs to the small GTPase superfamily. SAR1 family

• 细胞定位：
• Endoplasmic reticulum membrane ; Peripheral membrane protein . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein . Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region. .

• 组织表达：
• Expressed in many tissues including small intestine, liver, muscle and brain.

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