• 靶点：
• M-RIP

• 基因名称：
• MPRIP

• 蛋白名称：
• Myosin phosphatase Rho-interacting protein

• Human Gene Id：
• 23164/23164

• Human Swiss Prot No：
• Q6WCQ1

• Mouse Gene Id：
• 26936

• Mouse Swiss Prot No：
• P97434

• Rat Gene Id：
• 116504

• Rat Swiss Prot No：
• Q9ERE6

• 免疫原：
• Synthesized peptide derived from the Internal region of human M-RIP.

• 特异性：
• M-RIP Polyclonal Antibody detects endogenous levels of M-RIP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MPRIP;KIAA0864;MRIP;RHOIP3;Myosin phosphatase Rho-interacting protein;M-RIP;Rho-interacting protein 3;RIP3;p116Rip

• 实测条带：
• 115kD

• 背景：
• function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,

• 功能：
• function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,

• 细胞定位：
• Cytoplasm, cytoskeleton . Colocalizes with F-actin.

• 组织表达：
• Aorta,Brain,Epithelium,Lymph,Melanoma,Muscle,Ovary,Tongue,

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