• 靶点：
• Ribosomal Protein L11

• 简介：
• >>Ribosome;>>Coronavirus disease - COVID-19

• 基因名称：
• RPL11

• 蛋白名称：
• 60S ribosomal protein L11

• Human Gene Id：
• 6135

• Human Swiss Prot No：
• P62913

• Mouse Gene Id：
• 67025

• Mouse Swiss Prot No：
• Q9CXW4

• Rat Swiss Prot No：
• P62914

• 免疫原：
• Synthesized peptide derived from Ribosomal Protein L11 . at AA range: 100-180

• 特异性：
• Ribosomal Protein L11 Polyclonal Antibody detects endogenous levels of Ribosomal Protein L11 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RPL11;60S ribosomal protein L11;CLL-associated antigen KW-12

• 实测条带：
• 20kD

• 背景：
• Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010],

• 功能：
• disease:Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7) [MIM:612562]. DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,function:Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits.,similarity:Belongs to the ribosomal protein L5P family.,

• 细胞定位：
• Nucleus, nucleolus . Cytoplasm .

• 组织表达：
• Amygdala,Cervix carcinoma,Tonsil,

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