• 靶点：
• RASSF6

• 简介：
• >>Hippo signaling pathway;>>Hippo signaling pathway - multiple species

• 基因名称：
• RASSF6

• 蛋白名称：
• Ras association domain-containing protein 6

• Human Gene Id：
• 166824

• Human Swiss Prot No：
• Q6ZTQ3

• Mouse Swiss Prot No：
• Q80UQ2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RASSF6. AA range:129-178

• 特异性：
• RASSF6 Polyclonal Antibody detects endogenous levels of RASSF6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RASSF6;Ras association domain-containing protein 6

• 实测条带：
• 45kD

• 背景：
• This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012],

• 功能：
• function:May act as a Ras effector protein.,sequence caution:Translated as Gln.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,

• 组织表达：
• Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.

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