• 靶点：
• Raftlin

• 基因名称：
• RFTN1

• 蛋白名称：
• Raftlin

• Human Gene Id：
• 23180

• Human Swiss Prot No：
• Q14699

• Mouse Swiss Prot No：
• Q6A0D4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RFTN1. AA range:432-481

• 特异性：
• Raftlin Polyclonal Antibody detects endogenous levels of Raftlin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RFTN1;KIAA0084;MIG2;Raftlin;Cell migration-inducing gene 2 protein;Raft-linking protein

• 实测条带：
• 65kD

• 背景：
• function:May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.,similarity:Belongs to the raftlin family.,subcellular location:Associates with lipid rafts.,tissue specificity:Specifically expressed by B-cells (at protein level).,

• 功能：
• function:May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.,similarity:Belongs to the raftlin family.,subcellular location:Associates with lipid rafts.,tissue specificity:Specifically expressed by B-cells (at protein level).,

• 细胞定位：
• Cell membrane ; Lipid-anchor . Cytoplasm . Membrane raft . Endosome . Early endosome . Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). .

• 组织表达：
• Expressed in B-cells (at protein level) (PubMed:12805216). Expressed in dendritic cells and macrophages (PubMed:27022195, PubMed:21266579).

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