• 靶点：
• Rab11-FIP4

• 简介：
• >>Endocytosis

• 基因名称：
• RAB11FIP4

• 蛋白名称：
• Rab11 family-interacting protein 4

• Human Gene Id：
• 84440

• Human Swiss Prot No：
• Q86YS3

• Mouse Gene Id：
• 268451

• Mouse Swiss Prot No：
• Q8BQP8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RAB11FIP4. AA range:452-501

• 特异性：
• Rab11-FIP4 Polyclonal Antibody detects endogenous levels of Rab11-FIP4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RAB11FIP4;ARFO2;KIAA1821;Rab11 family-interacting protein 4;FIP4-Rab11;Rab11-FIP4;Arfophilin-2

• 实测条带：
• 95kD

• 背景：
• Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Apr 2008],

• 功能：
• function:A Rab11 effector protein acting in the endosomal trafficking.,similarity:Contains 1 EF-hand domain.,subcellular location:Colocalizes with RAB11A in the endocytic recycling compartment (ERC).,subunit:Homooligomer. Forms an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with RAB11A that has been activated by GTP binding.,

• 细胞定位：
• Endosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recycling endosome membrane ; Peripheral membrane protein. Cleavage furrow . Midbody . Cytoplasmic vesicle . Recruited to the cleavage furrow and the midbody during cytokinesis. .

• 组织表达：
• Present at high level in testis (at protein level). Weakly expressed in other tissues.

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