• 靶点：
• PSD95

• 简介：
• >>Hippo signaling pathway;>>Glutamatergic synapse;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Cocaine addiction

• 基因名称：
• DLG4

• 蛋白名称：
• Disks large homolog 4

• Human Gene Id：
• 1742

• Human Swiss Prot No：
• P78352

• Mouse Gene Id：
• 13385

• Mouse Swiss Prot No：
• Q62108

• Rat Gene Id：
• 29495

• Rat Swiss Prot No：
• P31016

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PSD-95. AA range:253-302

• 特异性：
• PSD-95 Polyclonal Antibody detects endogenous levels of PSD-95 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DLG4;PSD95;Disks large homolog 4;Postsynaptic density protein 95;PSD-95;Synapse-associated protein 90;SAP-90;SAP90

• 实测条带：
• 95kD

• 背景：
• This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.,domain:The PDZ domain 3 mediates interaction with ADR1B.,function:Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.,PTM:Palmitoylation of isoform 1 is required for targeting to postsynaptic density.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 PDZ (DHR) domains.,similarity:Contains 3

• 细胞定位：
• Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cytoplasm . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cell junction, synapse, presynapse . High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. .

• 组织表达：
• Brain.

TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway FREE RADICAL BIOLOGY AND MEDICINE Ying Cheng, Yuan Gao, Jing Li, Tongyu Rui, Qianqian Li, Huan Chen, Bowen Jia, Yiting Song, Zhiya Gu, Tao Wang, Cheng Gao, Ying Wang, Zufeng Wang, Fudi Wang, Luyang Tao, Chengliang Luo WB Mouse Ipsilateral cerebral cortex
货号：YT3879

Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood. Brain and Behavior Brain Behav. 2020 Oct;10(10):e01801 WB Rat 1 : 1500 Hippocampal tissue
货号：YT3879

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