• 靶点：
• PD2R

• 简介：
• >>Neuroactive ligand-receptor interaction

• 基因名称：
• PTGDR

• 蛋白名称：
• Prostaglandin D2 receptor

• Human Gene Id：
• 5729

• Human Swiss Prot No：
• Q13258

• Mouse Swiss Prot No：
• P70263

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PTGDR. AA range:263-312

• 特异性：
• PD2R Polyclonal Antibody detects endogenous levels of PD2R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PTGDR;Prostaglandin D2 receptor;PGD receptor;PGD2 receptor;Prostanoid DP receptor

• 实测条带：
• 40kD

• 背景：
• This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

• 功能：
• disease:Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1) [MIM:607277]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea.,function:Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.

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