• 靶点：
• PARP-4

• 简介：
• >>Base excision repair;>>Apoptosis

• 基因名称：
• PARP4

• 蛋白名称：
• Poly [ADP-ribose] polymerase 4

• Human Gene Id：
• 143

• Human Swiss Prot No：
• Q9UKK3

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PARP4. AA range:1151-1200

• 特异性：
• PARP-4 Polyclonal Antibody detects endogenous levels of PARP-4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PARP4;ADPRTL1;KIAA0177;PARPL;Poly [ADP-ribose] polymerase 4;PARP-4;193 kDa vault protein;ADP-ribosyltransferase diphtheria toxin-like 4;ARTD4;PARP-related/IalphaI-related H5/proline-rich;PH5P;Vault poly(ADP-ribose) polymerase;VP

• 分子量：
• 193kD

• 背景：
• This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 VWFA domain.,subcellular location:Also found in the nucleus, associated with mitotic spindles.,subunit:Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1.,tissue specificity:Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.,

• 细胞定位：
• Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Also found in the nucleus, associated with mitotic spindles. .

• 组织表达：
• Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

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