PAR-3 Polyclonal Antibody
- 货号：YT3586
- 应用：IF;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades
- 蛋白名称：
- Proteinase-activated receptor 3
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87
- 特异性：
- PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- F2RL2;PAR3;Proteinase-activated receptor 3;PAR-3;Coagulation factor II receptor-like 2;Thrombin receptor-like 2
- 背景：
- This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012],
- 功能：
- function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
- Immunofluorescence analysis of MCF7 cells, using F2RL2 Antibody. The picture on the right is blocked with the synthesized peptide.
