• 靶点：
• PAF-R

• 简介：
• >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Staphylococcus aureus infection

• 基因名称：
• PTAFR

• 蛋白名称：
• Platelet-activating factor receptor

• Human Gene Id：
• 5724

• Human Swiss Prot No：
• P25105

• Mouse Gene Id：
• 19204

• Mouse Swiss Prot No：
• Q62035

• Rat Gene Id：
• 58949

• Rat Swiss Prot No：
• P46002

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243

• 特异性：
• PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PTAFR;PAFR;Platelet-activating factor receptor;PAF-R;PAFr

• 分子量：
• 39kD

• 背景：
• This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

• 功能：
• function:Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.,induction:By granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.

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