• 靶点：
• PA26

• 简介：
• >>p53 signaling pathway;>>Longevity regulating pathway

• 基因名称：
• SESN1

• 蛋白名称：
• Sestrin-1

• Human Gene Id：
• 27244

• Human Swiss Prot No：
• Q9Y6P5

• Mouse Gene Id：
• 140742

• Mouse Swiss Prot No：
• P58006

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320

• 特异性：
• PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SESN1;PA26;SEST1;Sestrin-1;p53-regulated protein PA26

• 实测条带：
• 57kD

• 背景：
• This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

• 功能：
• disease:Defects in SESN1 may be involved in heterotaxia. Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems.,function:Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.,induction:Isoforms T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. Isoform T1 is not induced by p53.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,

• 细胞定位：
• Nucleus . Cytoplasm .

• 组织表达：
• Widely expressed.

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