• 靶点：
• OX2R

• 简介：
• >>Kaposi sarcoma-associated herpesvirus infection

• 基因名称：
• CD200R1

• 蛋白名称：
• Cell surface glycoprotein CD200 receptor 1

• Human Gene Id：
• 131450

• Human Swiss Prot No：
• Q8TD46

• Mouse Swiss Prot No：
• Q9ES57

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MOX2R. AA range:241-290

• 特异性：
• OX2R Polyclonal Antibody detects endogenous levels of OX2R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD200R1;CD200R;CRTR2;MOX2R;OX2R;Cell surface glycoprotein CD200 receptor 1;CD200 cell surface glycoprotein receptor;Cell surface glycoprotein OX2 receptor 1

• 实测条带：
• 37kD

• 背景：
• This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

• 功能：
• function:Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.,PTM:The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.,similarity:Belongs to the CD200R family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with Human herpesvirus 8 vOX2 protein.,tissue specificity:Expressed in granulocytes, monocytes, most T cells, neutrophils, basophils and a subset of NK, NKT and B cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.,

• 细胞定位：
• [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.

• 组织表达：
• Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

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