• 靶点：
• OPN

• 简介：
• >>PI3K-Akt signaling pathway;>>Apelin signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Toll-like receptor signaling pathway;>>GnRH secretion;>>Human papillomavirus infection

• 基因名称：
• SPP1

• 蛋白名称：
• Osteopontin

• Human Gene Id：
• 6696

• Human Swiss Prot No：
• P10451

• Mouse Gene Id：
• 20750

• Mouse Swiss Prot No：
• P10923

• Rat Gene Id：
• 25353

• Rat Swiss Prot No：
• P08721

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Osteopontin. AA range:261-310

• 特异性：
• OPN Polyclonal Antibody detects endogenous levels of OPN protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SPP1;BNSP;OPN;PSEC0156;Osteopontin;Bone sialoprotein 1;Nephropontin;Secreted phosphoprotein 1;SPP-1;Urinary stone protein;Uropontin

• 实测条带：
• 60kD

• 背景：
• secreted phosphoprotein 1(SPP1) Homo sapiens The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• 功能：
• disease:This protein plays a principal role in urinary stone formation as the stone matrix.,function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.,function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.,online information:Osteopontin entry,PTM:Extensively phosphorylated on clustered serine residues.,PTM:N- and O-glycosylated.,similarity:Belongs to the osteopontin family.,subunit:Ligand for integrin alpha-V/beta-3.,

• 细胞定位：
• Secreted.

• 组织表达：
• Bone. Found in plasma.

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