• 靶点：
• O-FucT-2

• 简介：
• >>Other types of O-glycan biosynthesis

• 基因名称：
• POFUT2

• 蛋白名称：
• GDP-fucose protein O-fucosyltransferase 2

• Human Gene Id：
• 23275

• Human Swiss Prot No：
• Q9Y2G5

• Mouse Gene Id：
• 80294

• Mouse Swiss Prot No：
• Q8VHI3

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human POFUT2. AA range:361-410

• 特异性：
• O-FucT-2 Polyclonal Antibody detects endogenous levels of O-FucT-2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• POFUT2;C21orf80;FUT13;KIAA0958;GDP-fucose protein O-fucosyltransferase 2;Peptide-O-fucosyltransferase 2;O-FucT-2

• 分子量：
• 50kD

• 背景：
• Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008],

• 功能：
• catalytic activity:Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.,function:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats.,online information:GlycoGene database,online information:Peptide-O-fucosyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 68 family.,tissue specificity:Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.,

• 细胞定位：
• Endoplasmic reticulum . Golgi apparatus . Mainly located in the endoplasmic reticulum. .

• 组织表达：
• Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.

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