• 靶点：
• O-FucT-1

• 简介：
• >>Other types of O-glycan biosynthesis

• 基因名称：
• POFUT1

• 蛋白名称：
• GDP-fucose protein O-fucosyltransferase 1

• Human Gene Id：
• 23509

• Human Swiss Prot No：
• Q9H488

• Mouse Gene Id：
• 140484

• Mouse Swiss Prot No：
• Q91ZW2

• Rat Gene Id：
• 311551

• Rat Swiss Prot No：
• Q6EV70

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human POFUT1. AA range:331-380

• 特异性：
• O-FucT-1 Polyclonal Antibody detects endogenous levels of O-FucT-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• POFUT1;FUT12;KIAA0180;GDP-fucose protein O-fucosyltransferase 1;Peptide-O-fucosyltransferase 1;O-FucT-1

• 实测条带：
• 44kD

• 背景：
• This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.,cofactor:Manganese.,function:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling.,online information:GlycoGene database,online information:Peptide-O-fucosyltransferase 1,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 68 family.,tissue specificity:Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,

• 细胞定位：
• Endoplasmic reticulum .

• 组织表达：
• Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

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