OB-cadherin Polyclonal Antibody
- 货号：YT3224
- 应用：WB;ELISA
- 种属：Human;Mouse
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CDH11. AA range:421-470
- 特异性：
- OB-cadherin Polyclonal Antibody detects endogenous levels of OB-cadherin protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CDH11;Cadherin-11;OSF-4;Osteoblast cadherin;OB-cadherin
- 背景：
- This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008],
- 功能：
- function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.,
- 细胞定位：
- Cell membrane; Single-pass type I membrane protein.
- 组织表达：
- Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
- Western Blot analysis of Jurkat cells using OB-cadherin Polyclonal Antibody
- Western blot analysis of lysates from Jurkat cells, using CDH11 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HeLa cells using Cytochrome P450 1A1/2 antibody.
