N-Shc Polyclonal Antibody
- 货号:YT3196
- 应用:IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>Neurotrophin signaling pathway;>>Insulin signaling pathway;>>Estrogen signaling pathway;>>Prolactin signaling pathway;>>Relaxin signaling pathway;>>Growth hormone synthesis, secretion and action;>>Alcoholism;>>Bacterial invasion of epithelial cells;>>Glioma;>>Chronic myeloid leukemia;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
- 蛋白名称:
- SHC-transforming protein 3
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human SHC3. AA range:291-340
- 特异性:
- N-Shc Polyclonal Antibody detects endogenous levels of N-Shc protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- SHC3;NSHC;SHCC;SHC-transforming protein 3;Neuronal Shc;N-Shc;Protein Rai;SHC-transforming protein C;Src homology 2 domain-containing-transforming protein C3;SH2 domain protein C3
- 背景:
- function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
- 功能:
- function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
- 细胞定位:
- cytosol,plasma membrane,
- 组织表达:
- Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
![](/uploadfiles/PIC/yt3196_pic758318522.jpg)
- Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SHC3 Antibody. The picture on the right is blocked with the synthesized peptide.