• 靶点：
• NKp30

• 简介：
• >>Natural killer cell mediated cytotoxicity

• 基因名称：
• NCR3

• 蛋白名称：
• Natural cytotoxicity triggering receptor 3

• Human Gene Id：
• 259197

• Human Swiss Prot No：
• O14931

• Rat Swiss Prot No：
• Q8CFD9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human NCR3. AA range:104-153

• 特异性：
• NKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NCR3;1C7;LY117;Natural cytotoxicity triggering receptor 3;Activating natural killer receptor p30;Natural killer cell p30-related protein;NK-p30;NKp30;CD antigen CD337

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],

• 功能：
• function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subunit:Interacts with CD3Z.,tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein .

• 组织表达：
• Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

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