Neurocalcin δ Polyclonal Antibody
- 货号：YT3063
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Olfactory transduction
- 免疫原：
- Synthesized peptide derived from Neurocalcin δ . at AA range: 370-450
- 特异性：
- Neurocalcin δ Polyclonal Antibody detects endogenous levels of Neurocalcin δ protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- NCALD;Neurocalcin-delta
- 背景：
- This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
- 功能：
- function:May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.,
- 细胞定位：
- intracellular,cytosol,clathrin coat of trans-Golgi network vesicle,extracellular exosome,
- 组织表达：
- Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
- Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
