• 靶点：
• MYH

• 简介：
• >>Base excision repair

• 基因名称：
• MUTYH

• 蛋白名称：
• A/G-specific adenine DNA glycosylase

• Human Gene Id：
• 4595

• Human Swiss Prot No：
• Q9UIF7

• Mouse Gene Id：
• 70603

• Mouse Swiss Prot No：
• Q99P21

• Rat Gene Id：
• 170841

• Rat Swiss Prot No：
• Q8R5G2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MUTYH. AA range:151-200

• 特异性：
• MYH Polyclonal Antibody detects endogenous levels of MYH protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MUTYH;MYH;A/G-specific adenine DNA glycosylase;MutY homolog;hMYH

• 实测条带：
• 60kD

• 背景：
• This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,disease:Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM:608456].,disease:Defects in MUTYH are a cause of gastric cancer [MIM:137215].,function:Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.,similarity:Belongs to the nth/mutY family.,similarity:Contains 1 nudix hydrolase domain.,

• 细胞定位：
• Nucleus . Mitochondrion .

• 组织表达：
• Kidney,

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