MYBPC1 Polyclonal Antibody
- 货号：YT2926
- 应用：WB;ELISA;IHC
- 种属：Human;Mouse;Rat
- 蛋白名称：
- Myosin-binding protein C slow-type
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human MYBPC1. AA range:218-267
- 特异性：
- MYBPC1 Polyclonal Antibody detects endogenous levels of MYBPC1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- MYBPC1;MYBPCS;Myosin-binding protein C; slow-type;Slow MyBP-C;C-protein, skeletal muscle slow isoform
- 背景：
- This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
- 功能：
- function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.,similarity:Belongs to the immunoglobulin superfamily. MyBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,
- 细胞定位：
- cytosol,myofibril,myosin filament,
- 组织表达：
- Brain,Fetal skeletal muscle,Hippocampus,Liver,Muscle pool- 2 tissue
- Western Blot analysis of 293 cells using MYBPC1 Polyclonal Antibody diluted at 1:500
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
