• 靶点：
• MMP-16

• 简介：
• >>Parathyroid hormone synthesis, secretion and action;>>MicroRNAs in cancer

• 基因名称：
• MMP16

• 蛋白名称：
• Matrix metalloproteinase-16

• Human Gene Id：
• 4325

• Human Swiss Prot No：
• P51512

• Mouse Gene Id：
• 17389

• Mouse Swiss Prot No：
• Q9WTR0

• Rat Gene Id：
• 65205

• Rat Swiss Prot No：
• O35548

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MMP-16. AA range:551-600

• 特异性：
• MMP-16 Polyclonal Antibody detects endogenous levels of MMP-16 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MMP16;MMPX2;Matrix metalloproteinase-16;MMP-16;MMP-X2;Membrane-type matrix metalloproteinase 3;MT-MMP 3;MTMMP3;Membrane-type-3 matrix metalloproteinase;MT3-MMP;MT3MMP

• 实测条带：
• 70kD

• 背景：
• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010],

• 功能：
• cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,developmental stage:Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.,function:Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at low

• 细胞定位：
• [Isoform Long]: Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.

• 组织表达：
• Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

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