MRGX1 Polyclonal Antibody
- 货号:YT2835
- 应用:WB;IHC
- 种属:Human;Rat;Mouse;
- 蛋白名称:
- Mas-related G-protein coupled receptor member X1
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human MRGX1. AA range:271-320
- 特异性:
- MRGX1 Polyclonal Antibody detects endogenous levels of MRGX1 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000;IHC 1:50-300
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- MRGPRX1;MRGX1;SNSR3;SNSR4;Mas-related G-protein coupled receptor member X1;Sensory neuron-specific G-protein coupled receptor 3/4
- 背景:
- function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.,
- 功能:
- function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.,
- 细胞定位:
- Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
![](/uploadfiles/PIC/yt2835_pic854318522.jpg)
- Immunofluorescence analysis of HepG2 cells, using MRGX1 Antibody. The picture on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/yt2835_pic854418522.jpg)
- Western blot analysis of lysates from MCF-7 cells, using MRGX1 Antibody. The lane on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/26feilinaicc.jpg)
- Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).