• 靶点：
• MN1

• 基因名称：
• MN1

• 蛋白名称：
• Probable tumor suppressor protein MN1

• Human Gene Id：
• 4330

• Human Swiss Prot No：
• Q10571

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MN1. AA range:821-870

• 特异性：
• MN1 Polyclonal Antibody detects endogenous levels of MN1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MN1;Probable tumor suppressor protein MN1

• 实测条带：
• 135kD

• 背景：
• Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008],

• 功能：
• disease:A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.,disease:Defects in MN1 may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.,function:May play a role in tumor suppression.,tissue specificity:Ubiquitously expressed. Highest levels in skeletal muscle.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.

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