• 靶点：
• MLC-2

• 简介：
• >>Axon guidance;>>Focal adhesion;>>Tight junction;>>Platelet activation;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Shigellosis;>>Salmonella infection

• 基因名称：
• MYL12A

• 蛋白名称：
• Myosin regulatory light chain 12A

• Human Gene Id：
• 10398/10627

• Human Swiss Prot No：
• P19105/O14950/P24844

• Mouse Gene Id：
• 67938/98932

• Rat Gene Id：
• 50685/296313

• Rat Swiss Prot No：
• P18666/Q64122

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MLC-2. AA range:5-54

• 特异性：
• MLC-2 Polyclonal Antibody detects endogenous levels of MLC-2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MYL12A;MLCB;MRLC3;RLC;Myosin regulatory light chain 12A;MLC-2B;Myosin RLC;Myosin regulatory light chain 2; nonsarcomeric;Myosin regulatory light chain MRLC3;MYL12B;MRLC2;MYLC2B;Myosin regulatory light chain 12B;MLC-2A;MLC-2;M

• 分子量：
• 20kD

• 背景：
• This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014],

• 功能：
• function:Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.,miscellaneous:This chain binds calcium.,PTM:Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,

• 细胞定位：
• stress fiber,cytosol,brush border,myosin complex,myosin II complex,Z disc,apical part of cell,extracellular exosome,

• 组织表达：
• Coronary artery,Epithelium,Placenta,Skeletal muscle,Skin,Testis,

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