MEK Kinase-6 Polyclonal Antibody
- 货号：YT2710
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>MAPK signaling pathway
- 蛋白名称：
- Mitogen-activated protein kinase kinase kinase 6
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330
- 特异性：
- MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- MAP3K6;ASK2;MAPKKK6;MEKK6;Mitogen-activated protein kinase kinase kinase 6;Apoptosis signal-regulating kinase 2
- 背景：
- This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
- 功能：
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
- 组织表达：
- Brain,PCR rescued clones,Skin,
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MAP3K6 Antibody. The picture on the right is blocked with the synthesized peptide.
