• 靶点：
• MC2-R

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome

• 基因名称：
• MC2R

• 蛋白名称：
• Adrenocorticotropic hormone receptor

• Human Gene Id：
• 4158

• Human Swiss Prot No：
• Q01718

• Mouse Gene Id：
• 17200

• Mouse Swiss Prot No：
• Q64326

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297

• 特异性：
• MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MC2R;ACTHR;Adrenocorticotropic hormone receptor;ACTH receptor;ACTH-R;Adrenocorticotropin receptor;Melanocortin receptor 2;MC2-R

• 实测条带：
• 34kD

• 背景：
• MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014],

• 功能：
• disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Melanocytes and corticoadrenal tissue.

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