• 靶点：
• MAGI-2

• 简介：
• >>Rap1 signaling pathway;>>PI3K-Akt signaling pathway

• 基因名称：
• MAGI2

• 蛋白名称：
• Membrane-associated guanylate kinase WW and PDZ domain-containing protein 2

• Human Gene Id：
• 9863

• Human Swiss Prot No：
• Q86UL8

• Mouse Gene Id：
• 50791

• Mouse Swiss Prot No：
• Q9WVQ1

• Rat Gene Id：
• 113970

• Rat Swiss Prot No：
• O88382

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MAGI2. AA range:221-270

• 特异性：
• MAGI-2 Polyclonal Antibody detects endogenous levels of MAGI-2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MAGI2;ACVRINP1;AIP1;KIAA0705;Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2;Atrophin-1-interacting protein 1;AIP-1;Atrophin-1-interacting protein A;Membrane-associated guanylate kinase inverted 2;MAGI-

• 实测条带：
• 156kD

• 背景：
• The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008],

• 功能：
• function:Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 2 WW domains.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:Membrane-associated in synaptosomes.,subunit:Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By similarity). Interacts through its guanylate kinase domain with DLGAP1 (By similarity). Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2

• 细胞定位：
• Cytoplasm . Late endosome . Cell junction, synapse, synaptosome . Cell membrane ; Peripheral membrane protein . Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). .

• 组织表达：
• Specifically expressed in brain.

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