• 靶点：
• LPAAT-γ

• 简介：
• >>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Metabolic pathways;>>Phospholipase D signaling pathway

• 基因名称：
• AGPAT3

• 蛋白名称：
• 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

• Human Gene Id：
• 56894

• Human Swiss Prot No：
• Q9NRZ7

• Mouse Gene Id：
• 28169

• Mouse Swiss Prot No：
• Q9D517

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AGPAT3. AA range:121-170

• 特异性：
• LPAAT-γ Polyclonal Antibody detects endogenous levels of LPAAT-γ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AGPAT3;1-acyl-sn-glycerol-3-phosphate acyltransferase gamma;1-acylglycerol-3-phosphate O-acyltransferase 3;1-AGP acyltransferase 3;1-AGPAT 3;Lysophosphatidic acid acyltransferase gamma;LPAAT-gamma

• 实测条带：
• 40kD

• 背景：
• The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,function:Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus envelope .

• 组织表达：
• Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.

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