• 靶点：
• LOST1

• 基因名称：
• TUSC5

• 蛋白名称：
• Tumor suppressor candidate 5

• Human Gene Id：
• 286753

• Human Swiss Prot No：
• Q8IXB3

• Mouse Swiss Prot No：
• Q8C838

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TUSC5. AA range:1-50

• 特异性：
• LOST1 Polyclonal Antibody detects endogenous levels of LOST1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TUSC5;IFITMD3;LOST1;Tumor suppressor candidate 5;Dispanin subfamily B member 1;DSPB1;Interferon-induced transmembrane domain-containing protein D3;Protein located at seventeen-p-thirteen point three 1

• 实测条带：
• 22kD

• 背景：
• developmental stage:Expressed in fetal brain.,function:May be involved in fat metabolism.,similarity:Belongs to the CD225 family.,tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.,

• 功能：
• developmental stage:Expressed in fetal brain.,function:May be involved in fat metabolism.,similarity:Belongs to the CD225 family.,tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.,

• 细胞定位：
• Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm, perinuclear region . Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. .

• 组织表达：
• Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).

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