• 靶点：
• KOR-1

• 简介：
• >>Neuroactive ligand-receptor interaction

• 基因名称：
• OPRK1

• 蛋白名称：
• Kappa-type opioid receptor

• Human Gene Id：
• 4986

• Human Swiss Prot No：
• P41145

• Mouse Gene Id：
• 18387

• Mouse Swiss Prot No：
• P33534

• Rat Gene Id：
• 29335

• Rat Swiss Prot No：
• P34975

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370

• 特异性：
• KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• OPRK1;OPRK;Kappa-type opioid receptor;K-OR-1;KOR-1

• 实测条带：
• 48kD

• 背景：
• This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],

• 功能：
• function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.,online information:Kappa opioid receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R1. Interacts with GABARAPL1.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Detected in brain and placenta.

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs