• 靶点：
• IRAK-M

• 简介：
• >>Neurotrophin signaling pathway

• 基因名称：
• IRAK3

• 蛋白名称：
• Interleukin-1 receptor-associated kinase 3

• Human Gene Id：
• 11213

• Human Swiss Prot No：
• Q9Y616

• Mouse Swiss Prot No：
• Q8K4B2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IRAK3. AA range:491-540

• 特异性：
• IRAK-M Polyclonal Antibody detects endogenous levels of IRAK-M protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IRAK3;Interleukin-1 receptor-associated kinase 3;IRAK-3;IL-1 receptor-associated kinase M;IRAK-M

• 实测条带：
• 68kD

• 背景：
• This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive kinase.,cofactor:Magnesium.,disease:Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.,function:Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.,similarity:Belongs to the protein kinase superfamily. TK

• 细胞定位：
• Cytoplasm . Nucleus . In dendritic cells, translocates into the nucleus upon IL33 stimulation. .

• 组织表达：
• Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383). Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454).

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