• 靶点：
• IL-5

• 简介：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Intestinal immune network for IgA production;>>Pathways in cancer;>>Asthma;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Allograft rejection

• 基因名称：
• IL5

• 蛋白名称：
• Interleukin-5

• Human Gene Id：
• 3567

• Human Swiss Prot No：
• P05113

• Mouse Gene Id：
• 16191

• Mouse Swiss Prot No：
• P04401

• Rat Swiss Prot No：
• Q08125

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IL-5. AA range:43-92

• 特异性：
• IL-5 Polyclonal Antibody detects endogenous levels of IL-5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IL5;Interleukin-5;IL-5;B-cell differentiation factor I;Eosinophil differentiation factor;T-cell replacing factor;TRF

• 实测条带：
• 30kD

• 背景：
• This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013],

• 功能：
• function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.,online information:Interleukin-5 entry,similarity:Belongs to the IL-5 family.,subunit:Homodimer; disulfide-linked.,

• 细胞定位：
• Secreted.

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