IL-17Rα Polyclonal Antibody
- 货号：YT2318
- 应用：WB;ELISA
- 种属：Human;Mouse
- 简介：
- >>Cytokine-cytokine receptor interaction;>>IL-17 signaling pathway;>>Alcoholic liver disease
- 蛋白名称：
- Interleukin-17 receptor A
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190
- 特异性：
- IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- IL17RA;IL17R;Interleukin-17 receptor A;IL-17 receptor A;IL-17RA;CDw217;CD antigen CD217
- 背景：
- Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],
- 功能：
- function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,
- 细胞定位：
- [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
- Western blot analysis of the lysates from HeLa cells using IL17RA antibody.
