• 靶点：
• Histone deacetylase 10

• 简介：
• >>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis

• 基因名称：
• HDAC10

• 蛋白名称：
• Histone deacetylase 10

• Human Gene Id：
• 83933

• Human Swiss Prot No：
• Q969S8

• Mouse Gene Id：
• 170787

• Mouse Swiss Prot No：
• Q6P3E7

• Rat Gene Id：
• 362981

• Rat Swiss Prot No：
• Q569C4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human HDAC10. AA range:10-59

• 特异性：
• Histone deacetylase 10 Polyclonal Antibody detects endogenous levels of Histone deacetylase 10 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HDAC10;Histone deacetylase 10;HD10

• 实测条带：
• 75kD

• 背景：
• The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

• 功能：
• catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Excluded from the nucleoli.,subunit:Interacts with HDAC2, HDAC3 and NCOR2.,tissue specificity:Ubiquitous. High expression in liver, spleen, pancreas and kidney.,

• 细胞定位：
• Cytoplasm . Nucleus . Excluded from nucleoli. .

• 组织表达：
• Widely expressed with high levels in liver and kidney.

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