• 靶点：
• HCN2

• 简介：
• >>cAMP signaling pathway;>>GnRH secretion

• 基因名称：
• HCN2

• 蛋白名称：
• Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

• Human Gene Id：
• 610

• Human Swiss Prot No：
• Q9UL51

• Mouse Gene Id：
• 15166

• Mouse Swiss Prot No：
• O88703

• Rat Gene Id：
• 114244

• Rat Swiss Prot No：
• Q9JKA9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human HCN2. AA range:491-540

• 特异性：
• HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HCN2;BCNG2;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;Brain cyclic nucleotide-gated channel 2;BCNG-2

• 实测条带：
• 100kD

• 背景：
• Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010],

• 功能：
• domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Highly expressed throughout the brain. Detected at low levels in heart.

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