Group VI iPLA2 Polyclonal Antibody

  • 货号:YT2073
  • 应用:WB;ELISA
  • 种属:Human;Mouse;Rat
    • 靶点:
    • Group VI iPLA2
    • 简介:
    • >>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>alpha-Linolenic acid metabolism;>>Metabolic pathways;>>Ras signaling pathway;>>Vascular smooth muscle contraction;>>Fc gamma R-mediated phagocytosis;>>Inflammatory mediator regulation of TRP channels
    • 基因名称:
    • PLA2G6
    • 蛋白名称:
    • 85/88 kDa calcium-independent phospholipase A2
    • Human Gene Id:
    • 8398
    • Human Swiss Prot No:
    • O60733
    • Mouse Swiss Prot No:
    • P97819
    • 免疫原:
    • Synthesized peptide derived from the Internal region of human Group VI iPLA2.
    • 特异性:
    • Group VI iPLA2 Polyclonal Antibody detects endogenous levels of Group VI iPLA2 protein.
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • PLA2G6;PLPLA9;85/88 kDa calcium-independent phospholipase A2;CaI-PLA2;Group VI phospholipase A2;GVI PLA2;Intracellular membrane-associated calcium-independent phospholipase A2 beta;iPLA2-beta;Patatin-like phospholipase domain-contai
    • 实测条带:
    • 90kD
    • 背景:
    • The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010],
    • 功能:
    • catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,disease:Defects in PLA2G6 are a cause of neurodegeneration with brain iron accumulation (NBIA) [MIM:610217]. NBIA comprises a clinically and genetically heterogeneous group of disorders with high basal ganglia iron.,disease:Defects in PLA2G6 are the cause of infantile neuroaxonal dystrophy 1 (INAD1) [MIM:256600]; also known as Seitelberger disease. Infantile neuroaxonal dystrophy (INAD) is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years.,disease:Defects in PLA2G6 are the cause of Karak syndrome [MIM:608395]. Karak syndrome is a neurologic disease characterized by early-onset progressive cerebellar ataxia, dystonia, spasticity, intellectual and features c
    • 细胞定位:
    • Cytoplasm . Cell membrane . Mitochondrion . Cell projection, pseudopodium . Recruited to the membrane-enriched pseudopods upon MCP1/CCL2 stimulation in monocytes. .
    • 组织表达:
    • Four different transcripts were found to be expressed in a distinct tissue distribution.