• 靶点：
• GNPAT

• 简介：
• >>Glycerophospholipid metabolism;>>Peroxisome

• 基因名称：
• GNPAT

• 蛋白名称：
• Dihydroxyacetone phosphate acyltransferase

• Human Gene Id：
• 8443

• Human Swiss Prot No：
• O15228

• Mouse Swiss Prot No：
• P98192

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GNPAT. AA range:231-280

• 特异性：
• GNPAT Polyclonal Antibody detects endogenous levels of GNPAT protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GNPAT;DAPAT;DHAPAT;Dihydroxyacetone phosphate acyltransferase;DAP-AT;DHAP-AT;Acyl-CoA:dihydroxyacetonephosphateacyltransferase;Glycerone-phosphate O-acyltransferase

• 实测条带：
• 77kD

• 背景：
• This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],

• 功能：
• catalytic activity:Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.,disease:Defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata type 2 (RCDP2) [MIM:222765]. RDCP2 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,pathway:Membrane lipid metabolism; glycerophospholipid metabolism.,similarity:Belongs to the GPAT/DAPAT family.,subcellular location:Exclusively localized to the lumenal side of the peroxisomal membrane.,subunit:May be part of an heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.,

• 细胞定位：
• Peroxisome membrane ; Peripheral membrane protein ; Matrix side . Exclusively localized to the lumenal side of the peroxisomal membrane. .

• 组织表达：
• Aorta endothelial cell,Brain,Liver,Lung,Thymus,

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